Toremifene: MedlinePlus Drug Information

Hypercalcemia (high calcium in the blood) and tumor flare (increased size of a tumor) are more likely to occur in patients with bone problems who are taking this medicine. Many of the breast cancer tumors will grow when estrogen is available in the body. As a result, the amount of estrogen that the tumor is exposed to is reduced, which will limit the growth of the tumor. Toremifene is used in postmenopausal women to treat metastatic breast cancer (cancer that has spread to other parts of the body). Your doctor may test your tumor before prescribing toremifene.

• Of the varying traits of Fareston, one of the more interesting is its relationship to testosterone.
• This is very promising evidence and information, but it should be understood that often times breast cancer patients will react very differently from healthy individuals to different drug treatments.
• Check with your physician for additional information about side effects.
• In liquid suspension, Toremifene is available in 30-60mg/ml and administered orally.

Use in Cancer

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Ten patients on anticonvulsants (phenobarbital, clonazepam, phenytoin, and carbamazepine) showed a twofold increase in clearance and a decrease in the elimination half-life of toremifene. Dose and concentration-related increases in the QTc interval and T wave changes were observed (see Table 1). These effects are believed to be caused by toremifene and N-demethyltoremiifene. Toremifene had no effects on heart rate, PR and QRS interval duration see BOX WARNING and WARNINGS AND PRECAUTIONS. Toremifene causes a decrease in the estradiol-induced vaginal cornification index in some postmenopausal women, indicative of its antiestrogenic activity. Toremifene also has estrogenic activity as shown by decreases in serum gonadotropin concentrations (FSH and LH).

Generic Fareston Availability

Toremifene citrate is a hormonal therapy that is FDA approved to treat hormone receptor-positive metastatic breast cancer. It is a SERM, or selective estrogen receptor modulator, a medicine that prevents estrogen signals from getting to breast cancer cells. Toremifene binds to estrogen receptors and may exert estrogenic, antiestrogenic, or both activities, depending upon the duration of treatment, animal species, gender, target organ, or endpoint selected.

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. The free Drugs.com Discount Card works like a coupon and can save you up to 80% or more off the cost of prescription medicines, over-the-counter drugs and pet prescriptions.

Usual Adult Dose for:

No significant age-related differences in FARESTON effectiveness or safety were noted. Theoretically, overdose may be manifested as an increase of antiestrogenic effects, such as hot flashes; estrogenic effects, such as vaginal bleeding; or nervous system disorders, such as vertigo, dizziness, ataxia, and nausea. There is no specific antidote and the treatment is symptomatic. In a study of 20 healthy subjects, 500 mg tolbutamide once daily (days 7 and 19) coadministered with toremifene as a 480 mg loading dose followed by 80 mg once daily for 16 days. Following coadministration on days 7 and 19 plasma tolbutamide Cmax and AUC were increased by less than 30%.